With the Premier League season a matter of weeks old, Old Trafford plays host to one of the games of the campaign, as United and City face off in the Manchester derby.
Spice is added by coaches Jose Mourinho and Pep Guardiola going head-to-head for the first time in English football, having rubbed each other up the wrong way while both were at Barcelona and then again when the Portuguese took charge at Real Madrid.
Both men have made an instant impact since taking charge of their new clubs in the summer, with both United and City having won three out of three in the league so far – meaning that something has to give on Saturday.
The Red Devils have conceded one goal in those three victories while summer recruit Zlatan Ibrahimovic has provided instant inspiration in attack, scoring in the 3-1 win at Bournemouth and netting twice in the 2-0 victory at home to Southampton.
The Swedish great is 13/10 to score at any time on Saturday but Mourinho may be tempted to hand teenage sensation Marcus Rashford a more prominent role after he grabbed a last-minute winner at Hull and then followed that up with a hat-trick for the England Under-21s.
He is a far more tempting 9/4 to find the net against the Citizens, who suffered at his hands last season when he netted the only goal of the game as the visitors won 1-0 at the Etihad Stadium.
Meanwhile, City boss Guardiola has his own conundrum to solve in attack, with Sergio Aguero ruled out by suspension after aiming a stray elbow at West Ham defender Winston Reid.
That leaves Kelechi Iheanacho waiting to step in, with the young Nigerian having scored eight goals in 29 Premier League appearances, 21 of which have come as a substitute.
However, scoring goals has not been a problem for the blue half of Manchester, with the Citizens having found the net nine times in their three league games so far this season.
They have, though, conceded against Sunderland, Stoke City and West Ham and will need to be a bit sharper at the back to hold off the threat of the likes of Ibrahimovic and Rashford, with the visitors 5/2 to keep a clean sheet at Old Trafford.
Last season the two Manchester derbies delivered just a Rashford goal between them and, despite the attacking talent sure to be on display, two goals in the game at 11/5 appears to be a reasonable price.