Arsenal appear to have got their season started after suffering an opening-day defeat at home to Liverpool and will have three points in mind when Southampton are the visitors.
The Gunners followed a 4-3 home loss to the Reds with a goalless draw at champions Leicester City before registering a first Premier League win of the campaign with a convincing 3-1 victory at Watford.
Boss Arsene Wenger even splashed the cash on deadline day to bring in Spanish forward Lucas Perez and Germany defender Shkodran Mustafi, with both men eyeing a club debut against the Saints.
Mesut Ozil impressed as the Hornets were swept aside, with Wenger expecting a better goal return from the German playmaker this season, especially when he is back to peak fitness.
Ozil, 33/10 to score first or last in the game, is key to the Gunners’ attacking play and should he add more regular goals to his repertoire, he can go a long way to ensuring the men from the Emirates Stadium are among the title hopefuls again.
The experience of Mustafi should also be a major boost, with the hosts 6/5 to keep a clean sheet against a Saints side still adjusting to the loss of key forwards Graziano Pelle and Sadio Mane over the summer.
Claude Puel takes his side to the capital still looking for a first win and a first clean sheet of the league season, having earned draws either side of a 2-0 loss at Manchester United.
Yet another summer of major changes has left new head coach Puel with much to ponder, while the loss of right-back Jeremy Pied to serious injury has only added to the problems.
Positives come with Jose Fonte having pledged his future to the club, while England left-back Ryan Bertrand is back in training and could feature against the Gunners.
Goals, not surprisingly, have been the main issue and Puel must hope that Jay Rodriguez can finally shake off his long-term injury problems to become a major player once again, with the centre-forward having netted a late equaliser in the 1-1 draw with Sunderland last time out.
Rodriguez is 33/10 to score at any time at the Emirates and with neither Shane Long nor Charlie Austin yet to find the net so far this season, Puel will be desperate to see Rodriguez continue his resurgence in style.
Recent omens do not look good for the Frenchman and his side, however, with Southampton failing to score on their last three visits to the Gunners, leaving Arsenal 29/20 to win the game to zero.