Dutch giants Ajax go into their second leg against FC Rostov in peril after a 1-1 draw at the Amsterdam Arena in the first leg.
The Russian side have never been to this stage before, far less the Champions League group stage itself.
They have, however, impressed in making steady progress and claimed the scalp of Anderlecht in the previous round.
Rostov were full value for their draw in Amsterdam and Ajax are 7/4 to achieve the away success they may need now to get through.
Boss Peter Bosz will take some solace from the fact Anderlecht twice led when they travelled to Rostov in the previous round as they brought home a 2-2 draw.
A similar result would be enough for Ajax now and is priced at 14/1. With both teams expected to score, there could well be value in that price.
FC Copenhagen are also set to travel with some trepidation when they face Apoel Nicosia.
The Danish outfit take a one-goal lead with them but they must cope with the hot and humid conditions in Cyprus.
Nicosia overturned a first-leg deficit to dump out Norwegian side Rosenborg last time out and they could well add another Scandinavian scalp here.
Salzburg have not graced the group phase of this competition for 20 years but the Austrians are rarely going to have a better chance after they returned from Zagreb with an away goal and a 1-1 draw.
The late penalty scored by Dinamo last week is the only goal Salzburg have conceded in their five-game European run to date.
The home side will be intent on keeping things tight and they are 5/4 to earn a shutout on home soil.
Alternatively, Salzburg are 29/20 to progress through this tie by winning the second leg without conceding a goal – just as they have done in four of five European outings to date.
Pep Guardiola’s first European home game as Manchester City boss is little more than a formality after Steaua Bucharest went down 5-0 at home.
The Romanians are unlikely to offer much resistance but, whatever team he selects, Guardiola’s City may not be fully focused here and the Romanians are 1/1 to score at the Etihad Stadium
It may be little more than a consolation but the visitors are capable of registering a goal.
Borussia Monchengladbach have seemingly done the hard work via their 3-1 win over Young Boys last week in Switzerland.
It would come as a major surprise should the Bundesliga outfit not confirm their superiority in this tie by recording victory on home soil and they are 10/27 to win the second leg.