The Premier League actions kicks off on Friday this week when Manchester United take on Southampton at Old Trafford.
The Red Devils seem to have taken on board Jose Mourinho’s demands, claiming the Community Shield before opening their Premier League campaign with Sunday’s 3-1 win away at Bournemouth.
Southampton also have a new man in charge but, in contrast, still appeared to be adapting to Claude Puel’s vision as they drew 1-1 at home to Watford on Saturday.
Following three years of frustration under David Moyes and Louis van Gaal, United look to have their mojo back under Mourinho.
The Portuguese spent big in the summer and Eric Bailly and Zlatan Ibrahimovic have both impressed although Henrikh Mkhitaryan is yet to flourish.
Friday night could see world-record signing Paul Pogba make an appearance for the first time since returning to the club after four years at Juventus.
Pogba and Chris Smalling both missed out at Bournemouth due to suspension but neither is likely to start following heavily disrupted pre-seasons due to their commitments at Euro 2016.
The signs look good for a home win at 5/12 but Southampton have enjoyed themselves at Old Trafford in recent years, not losing in their last three visits, including winning 1-0 at the Theatre of Dreams in each of the last two seasons.
They could also be boosted by the return of captain Jose Fonte who Puel says has a “good chance” of starting the match.
Fonte has been linked with a move to United but the Saints will be confident the defender remains focused and provide the leadership and composure he showed in Portugal’s surprise triumph at the European Championship.
A third straight win for Southampton at Old Trafford does, on paper, appear unlikely but their recent history suggests an away victory at 15/2 looks extremely tempting.
United are in rude health, though, and the sensible money could be on the home win although their defensive inconsistencies means a Both Teams To Score bet at 6/5 is certainly worth consideration.