Pep Guardiola begins his Champions League odyssey with Manchester City and they face a trip to face Steaua Bucharest in the play-off round.
The former Barcelona and Bayern Munich boss insists he has not moved to English football to prove himself as the best coach in the world. Fairly or otherwise, that is the tag most are expecting him to live up to.
Facing a first ever Champions League play-off round tie, City will be expected to make short work of the Romanian outfit and are 10/23 to bring home a first-leg advantage.
Guardiola has stressed the importance of securing an away goal in the tie so it seems fair to expect his side to take the game to their hosts.
With Sergio Aguero, Kevin de Bruyne and David Silva in tandem, City could have too many big guns for Steaua and they are 23/20 to overcome a one-goal handicap.
Four-time European champions Ajax are staring into the unknown as they face Russian newcomers FC Rostov.
Ajax will be wary of their visitors following Rostov’s 2-0 away win over Anderlecht to secure their passage to this play-off round.
Despite the fact the Dutch side have never beaten Russian opposition in this competition, losing all four games, they are expected to remedy that stat in the Amsterdam Arena and pick up a win at odds of 10/13.
Ajax boss Peter Bosz has admitted his side cannot afford to continue leaking goals against Rostov as they did in the previous round. Both teams to score in the first leg is priced at 11/10.
Champions League regulars FC Copenhagen will face familiar foes in Apoel Nicosia. The Cypriot side eliminated their Danish counterparts at this stage six years ago and arrive with Danish-born coach Thomas Christiansen looking to stage a repeat.
Copenhagen have scored 10 goals in their previous three home games and there could be more to come later. The Cypriot outfit, however, nicked a precious away goal at Rosenborg in the previous round, and Over 2.5 Goals, priced at 10/11, has plenty of appeal for this tussle in the Danish capital.
Swiss outfit Young Boys caused a stir in the last round when they knocked out Shakhtar Donetsk. Another stern test separates them from the group-stage draw as they face Bundesliga outfit Borussia Monchengladbach.
The sides shared six goals in a pre-season friendly last month and, at 13/5, another stalemate could be on the cards in this first-leg clash.
In the final Tuesday night clash, Austrian champions Salzburg will set about ending a run of three Champions League play-off tie losses.
They visit Dinamo Zagreb, a team they convincingly beat 4-2 and 5-1 when the sides went head-to-head in the Europa League two seasons ago.
With those results in mind, and four successive European wins in their locker, Salzburg could well be overpriced at 2/1 to carve out a first-leg win.